Michele Solimena Selected Research

Type 1 Diabetes Mellitus (Autoimmune Diabetes)

1/2019	ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor.
1/2018	Virus-like infection induces human β cell dedifferentiation.
10/2017	Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
3/2015	Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.
8/2014	PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells.
5/2012	Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.
1/2011	Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.

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Michele Solimena Research Topics

Disease

14	Type 2 Diabetes Mellitus (MODY) 11/2023 - 01/2010
12	Insulinoma 02/2024 - 07/2003
7	Insulin Resistance 11/2023 - 10/2013
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019 - 01/2011
3	Infections 03/2024 - 08/2014
3	Neoplasms (Cancer) 01/2015 - 02/2004
2	Prediabetic State (Prediabetes) 11/2023 - 05/2023
2	Chronic Pancreatitis 01/2022 - 07/2011
2	Brain Death (Brain Dead) 01/2022 - 01/2019
2	Fibrosis (Cirrhosis) 01/2020 - 10/2013
2	Inflammation (Inflammations) 01/2020 - 10/2013
2	Glucose Intolerance 01/2018 - 01/2015
2	Stiff-Person Syndrome (Stiff Man Syndrome) 02/2011 - 02/2004
1	Coxsackievirus Infections 03/2024
1	Disease Progression 01/2023
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	COVID-19 10/2021
1	Depressive Disorder (Melancholia) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Myocarditis (Carditis) 01/2020
1	Sleep Initiation and Maintenance Disorders (Insomnia) 03/2019
1	Sleep Wake Disorders 03/2019
1	Major Depressive Disorder (Major Depressive Disorders) 03/2019
1	Obesity 12/2018
1	Chronic Disease (Chronic Diseases) 01/2018
1	Virus Diseases (Viral Diseases) 01/2018
1	Hypoglycemia (Reactive Hypoglycemia) 08/2016
1	Cholestasis 01/2015
1	Pancreatitis 01/2015
1	Dehydration (Water Stress) 01/2013
1	Hypoxia (Hypoxemia) 09/2011
1	Pancreatic Diseases (Pancreatic Disease) 07/2011
1	Hyperplasia 11/2009
1	Hyperglycemia 11/2008
1	Muscle Rigidity 02/2004
1	Breast Neoplasms (Breast Cancer) 02/2004
1	Rhabdomyolysis 02/2004
1	Rare Diseases (Rare Disease) 02/2004

Drug/Important Bio-Agent (IBA)

15	Insulin (Novolin)FDA Link 02/2024 - 11/2008
9	Glucose (Dextrose)FDA LinkGeneric 11/2023 - 03/2009
5	Proteins (Proteins, Gene)FDA Link 01/2023 - 07/2003
4	Biomarkers (Surrogate Marker)IBA 03/2024 - 12/2021
4	Class 8 Receptor-Like Protein Tyrosine PhosphatasesIBA 01/2019 - 01/2008
4	AutoantigensIBA 01/2019 - 07/2003
3	RNA (Ribonucleic Acid)IBA 10/2021 - 01/2020
3	Melatonin Receptors (Melatonin Receptor)IBA 01/2021 - 03/2019
2	EpitopesIBA 03/2024 - 08/2023
2	LipidsIBA 11/2023 - 01/2023
2	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2015
2	Carrier Proteins (Binding Protein)IBA 10/2020 - 03/2009
2	Protein Isoforms (Isoforms)IBA 12/2012 - 02/2004
2	AntigensIBA 01/2011 - 02/2004
1	Antiviral Agents (Antivirals)IBA 03/2024
1	IncretinsIBA 05/2023
1	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 05/2023
1	Glucagon (Glukagon)FDA Link 05/2023
1	Glucagon-Like Peptide 1 (GLP 1)IBA 05/2023
1	GlicentinIBA 05/2023
1	B-insulinIBA 01/2022
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2021
1	ChromatinIBA 01/2021
1	ProinsulinIBA 10/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2020
1	CytokinesIBA 01/2020
1	MT2 Melatonin ReceptorIBA 01/2020
1	Retinaldehyde (Retinal)IBA 03/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2019
1	Collagenases (Collagenase)FDA Link 01/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	EnzymesIBA 12/2018
1	Actins (F Actin)IBA 08/2016
1	villinIBA 08/2016
1	Protein Tyrosine PhosphatasesIBA 03/2015
1	Tumor Biomarkers (Tumor Markers)IBA 01/2015
1	Complement System Proteins (Complement)IBA 10/2013
1	Interleukin-10 (Interleukin 10)IBA 10/2013
1	Anaphylatoxin C5a ReceptorIBA 10/2013
1	Indicators and Reagents (Reagents)IBA 01/2013
1	IceIBA 01/2013
1	Xylenes (Xylene)IBA 01/2013
1	3,5-diisopropylsalicylic acid (DIPS)IBA 01/2013
1	Ethanol (Ethyl Alcohol)IBA 01/2013
1	Transcription Factors (Transcription Factor)IBA 05/2012
1	Oxygen (Dioxygen)IBA 09/2011
1	Immunoglobulin G (IgG)IBA 02/2011
1	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)IBA 03/2009
1	Messenger RNA (mRNA)IBA 03/2009
1	Coat Protein Complex I (COPI)IBA 04/2008
1	Monomeric GTP-Binding ProteinsIBA 04/2008
1	Cyclin D1IBA 01/2008
1	amphiphysinIBA 02/2004

Therapy/Procedure

3	Pancreatectomy 01/2022 - 07/2011
3	Lasers (Laser) 01/2019 - 01/2013
2	Transplantation 10/2017 - 09/2011
1	Pancreaticoduodenectomy 01/2022
1	Therapeutics 01/2020
1	Immunotherapy 02/2004